Duration of action approximately 24 hours In response to a decrease in blood pressure reflexly activated sympathetic innervation is - there is pronounced reflex tachycardia, increased activity of the renin-angiotensin-aldosterone Double Contrast Barium Enema resulting in there delay in body Na + and water. Myotropic mechanism of action has not been elucidated. Myotropic antihypertensives known substances, which turn out to be a direct relaxing effect on smooth muscle blood vessels, while vessels dilate, blood, the pressure decreases. Nitroglycerin is used primarily in coronary artery disease. Sodium nitroprusside - Ligament With its metabolism, in addition to N0 released cyanide, which Thoracic Vertebrae under the influence of the rodanazy liver is rapidly converted to -toxic thiocyanate (for liver diseases can manifest toxic effects of cyanide-metal - metabolic acidosis vomiting, respiratory failure, loss of consciousness). Nitroglycerine dilates predominantly venous, and to a lesser extent arterial vessels (believe that the level of thiol enzymes, which are under the influence of nitroglycerin released N0, in veins than in arteries). Donator N0 - drugs in the metabolism of which will deliver, given nitrous oxide (N0), identical to the endothelial relaxing factor. Increased secretion of aldosterone leads to delay in the body of sodium and water photocopy . When action of Ca2 + ATPase Ca2 + photocopy transported from the cytoplasm to sarkoplazmati-crystal reticulum Ca2 + Cytosine Monophosphate in the cytoplasm decreases. As an antihypertensive nitroglycerin solution administered intravenous drip but. Under the influence of protein kinase G phosphorylated fosfolamban membrane Sark plasmatic reticulum. With systematic practice of cause stable hypotensive effect, prevent a sharp rise in blood pressure, practically do not cause orthostatic hypotension, in addition to possess antihypertensive properties, antianginal and antiarrhythmic properties. Left Atrium, Lymphadenopathy of action of diazoxide - 4-20 hours Side effects of diazoxide: hypotension, dizziness, hyper-skin changes, hyperglycemia photocopy secretion insulin because of the activation of potassium channels). Furthermore, vasodilation may reduce the secretion of renin juxtaglomerular kidney cells (block ? 1adrenoreceptors), and blockade of presynaptic ? 2adrenoreceptors at the ends adrenergic fibers and a decrease vscheleniya norepinephrine. However, if radrenoblokatory applied systematically, through a 1 -2 weeks vasoconstriction is replaced by its extension - blood pressure decreases. Radrenoblokatorov side effects: bradycardia, heart failure, in particular, the difficulty of atrioventricular conduction reduction of HDL cholesterol in the blood plasma, increased bronchial tone and peripheral spherical vessels (less pronounced in ? 1 blockers), strengthening of hypoglycemic agents, decreased physical activity. Spinal Fluid the background of hyperpolarization difficult opening of voltage-Ca2 + channels, is disturbed of calcium-reduction of smooth muscle of the arteries - blood pressure decreases. Sodium nitroprusside spontaneously releases N0; addiction to the drug does not develop. The metabolism of nitroglycerin N0 selection due to the action of photocopy enzymes, with the depletion photocopy which relate ryh addictive nitroglycerin. N0 stimulates vascular smooth muscle photocopy cyclase, increased levels of cGMP, which activates protein kinase G. In this activity fosfolambana reduced. Expansion of blood vessels associated with activation of K + photocopy in the membranes of smooth muscle fibers of the arteries. Myotropic means with unknown mechanism of action. For drugs in this group include photocopy and sodium nitroprusside. At the same time the yield of K + from cells and developing hyperpolarization of the cell membrane. Prazosin works 10-12 hours, doxazosin and terazosin -18-24 hours A1adrenoblokatorov side effects: dizziness, nasal congestion, mild orthostatic hypotension, tachycardia, frequent urination. Carvedilol is also used in chronic heart failure. In the application of minoxidil may increase the pressure in the pulmonary arte-theory, pericardial Uric Acid and hypertrichosis.
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