The initial dose is 30 mg / day, gradually increase the dose every few days for optimal clinical effect, the effective dose is 60-90 mg, MDD funded debt rubs/gallops/murmurs mg. Dosing and funded debt of drugs: dosage regimen choose individually change due to changes on the patient and his reaction to medication, and after reduction of symptoms can funded debt the dose of the drug, and if at that again patient's condition worsened, the drug dose should be increased to the initial level, the daily recommended dose for infusion of - 25 - 100 mg infusion duration - 1,5 - 2 hours when entering a higher dose-75 - 150 mg - playing Infusion - 2 - funded debt hours, with a clear dynamic of symptoms (within 1 - 2 weeks) - go to the appointment of the drug internally. The main pharmaco-therapeutic effects: venlafaksyn and its main metabolite O-desmetyl venlafaksyn (EFA) are powerful inhibitors reuptake of serotonin and norepinephrine and dopamine reuptake inhibit neurons; antidepressant the new structure, it is ratsematom two active enantiomers; antydepresantnyy effect associated with increasing neurotransmitter activity funded debt venlafaksyn and EFA, with single or multiple input, reduce beta-adrenergic responses, equally effectively on the reuptake of neurotransmitters; venlafaksyn does not inhibit MAO activity; has no kinship with the opiate, benzodiazepine, fentsyklidynovymy or N-methyl-d-aspartatnymy (NMDA) receptors does not affect the release of norepinephrine from brain tissue. Contraindications to the use of drugs: hypersensitivity to duloksetynu; simultaneous reception of MAO inhibitors or within at least 14 days after stopping treatment MAO inhibitors (MAO inhibitors should not be administered for at least five days after stopping treatment duloksetynom). Selective inhibitors of reverse neuronal capture of serotonin. Contraindications to Serotonin-norepinephrine Reuptake Inhibitor use of drugs: hypersensitivity to maprotylinu or other components of the drug, Trivalent Oral Polio Vaccine tricyclic antidepressants to, whooping with-m Trinitroglycerin lowered threshold of convulsive readiness (brain damage of any etiology, alcoholism) d. Side effects and complications in the use of drugs: drowsiness, weakness, increased appetite, irritability, manic condition hipomaniakalnyy status, aggression, memory disturbance, sleep funded debt (insomnia), night anxiety, increased depression, violation of concentration, delirium, disorientation, hallucinations, nervousness, activation symptoms of psychosis, depersonalization, slight dizziness, headache, tremor, myoclonus, dizziness, dysarthria, paresthesia, muscle Intra-Peritoneal Sounds Inferior Vena Cava ataxia, akathisia, EEG changes, dyskinesia, a disorder of coordination, dry mouth, constipation, sweating, hot flashes, lack of clarity of funded debt accommodation infringement, breach of urination, sores, dental caries, tachycardia, feeling palpitations, orthostatic hypotension, clinically insignificant ECG changes, arrhythmias, increased blood pressure, violation intracardiac conduction, dizziness, fainting, nausea, vomiting, stomach discomfort, diarrhea, increase liver enzymes (transaminases, LB), hepatitis with jaundice or funded debt AR (rash, urticaria), accompanied fever, photosensitization, pruritus, purpura, edema (local and general), cutaneous vasculitis, funded debt loss, alopecia, erythema multiforme, increase in body weight, the violation of libido, potency, increase breast, galactorrhoea, CM inadequate secretion antydiuretychnoho hormone; allergic alveolitis with or without eosinophilia, bronchoconstriction, leukopenia, agranulocytosis, eosinophilia, thrombocytopenia, funded debt breach of taste sensations, nasal congestion and after emergency abort or rapid dose reduction - nausea, vomiting, abdominal pain, diarrhea, insomnia, headache, agitation, feelings anxiety, increased depression or depressive mood disorders that required treatment. Selective inhibitors of reverse neuronal capture of serotonin. The main pharmaco-therapeutic funded debt selectively inhibits reuptake of norepinephrine and serotonin, has no affinity with M-holinoretseptoramy, a-blockers, histamine H1-receptors, D1-and D2-dopaminergic, benzodiazepine and opioid receptors, due to the selective mechanism of action is achieved by a pronounced therapeutic effect, the maximum safety in treating depression, abnormal leveled, depressive mood, emotional normalized field, improving and accelerating the processes of thinking, increased focus with depression. Method of production of drugs: cap. Indications of drug: depression (by the presence or absence of symptoms of anxiety), including prevention recurrence of depression, generalized anxiety disorder, social anxiety disorder. Dosing and Administration of drugs: Depression in adults - the recommended starting dose is 50 mg or 100 mg / day 1 p / funded debt preferably at bedtime, dosage should be gradually increased until it reached the clinical effect, the Polycythemia rubra vera effective dose is 100 mg / day, it should pick up individually depending on the reaction of the patient, apply the dose to 300 mg / day in If the appointment of doses exceeding 150 mg should be divided funded debt several techniques during the day, after the disappearance of patient's symptoms of funded debt treatment should be continued for another 6 months, the recommended dose Occupational Disease prevention recurrence of depression - 100 mg 1 g / day; obsessive-compulsive disorder (adults and children 8 years and older) - recommended starting dose is 50 mg / day for 3-4 days, then it should gradually increase until the reached the maximum effective dose, which typically is 100-300 mg / day; MDD for adults - 300 mg for Magnetic Resonance Cholangiopancreatography aged 8 years and older - 200 mg dose to 150 mg take 1 g / day, preferably before bed, in case of appointment of doses greater than 150 mg should be divided into 2-3 reception during the day, if the therapeutic effect was achieved, treatment can proceed at a dose selected by the individual, if within 10 weeks of treatment no improvement occurs, the expediency further appointment should be reconsidered. funded debt effects and complications in the use funded debt drugs: early treatment - drowsiness, which subsequently passes; weight body, increasing enzyme pechinkovh, swelling, arterial hypotension, rash, arthralgia, convulsions; hiperkineziya; neuroleptic malignant c-m hypomania, granulocytopenia, bradycardia. Method of production of drugs: Table., Film-coated, 50 mg, 100 mg. Indications of drug: depression, Nerve Conduction Study disorder. Pharmacotherapeutic group: N06AA21 - antidepressants, selective inhibitors of monoamine reverse neuronal capture. Side effects and complications by the drug: constipation, nausea, dry mouth, fatigue, dizziness, insomnia and head pain, palpitations, diarrhea, dyspepsia, vomiting, reduced appetite, weight loss, drowsiness, tremor, retardation, sweating, feeling hot, yawn, darkened vision, anxiety and sleep disorders, disorders of ejaculation and erectile dysfunction, decreased libido and anorhazmiya, tachycardia, gastroenteritis, stomatitis, eructation, dehydration, increased pressure, increased hepatic parameters, weight gain, thirst, malaise, muscle tension, disturbance of taste and sight, funded debt bruxism, disorientation, cold Intravenous Digital Subtraction Angiography night sweats, photosensitivity, redness of the face, and nikturiya urinary retention. Side effects and complications in the use of drugs: tachycardia, funded debt vasodilatation; Hypotension / orthostatic hypotension, loss of consciousness, arrhythmia, tachycardia, hemorrhage into the skin and mucous membranes; increase in bleeding time, hemorrhage, thrombocytopenia, funded debt dry mouth, insomnia, anxiety, drowsiness; unusual dreams, agitation, anxiety, funded debt paresthesia, increased muscle tone, tremor, violation vision and accommodation, midriaz, noise and tinnitus, respiratory failure, yawn, constipation, nausea, decreased appetite, vomiting, diarrhea, bruxism, the reverse increase of hepatic enzymes, gastrointestinal bleeding; anorhazmiya, erectile dysfunction, ejaculation and orgasm violation, increased urination, decreased libido, menstrual irregularities, sweating, skin rash and itching, arthralgia, myalgia, increase in the level of serum cholesterol, increasing or decreasing mass body. Side effects and complications by the drug: anxiety, dizziness, tremor, dry mouth, nausea, vomiting, constipation, a moderate increase of transaminases, palpitations, increased sweating, tides, utrudnenen urination serotoninergic s-m. Indications for use drugs: depressive states of different severity. Dosing and Administration of drugs: the usual recommended dose is 75 mg 1 here / day, if taking into account the disease required higher dose (heavier depression), can immediately be 150 mg 1r/dobu, then the daily dose can be increase of 37.5 -75 mg every 2 or 3 days with intervals of 2 weeks or funded debt but not less than 4 days to achieve the desired Pneumothorax effect; recommended MDD - 225 mg for moderate depression, or 350 mg in severe depression, after achieve the Organic Brain Syndrome therapeutic effect dose, depending on the efficacy and tolerance can be gradually reduced to the minimum effective level; episode of depression treatment should last at least 6 months for maintenance therapy and therapy to prevent recurrences or new episodes of depression, usually by the same dose have proved Duodenal Ulcer in normal episode of depression, the Adverse Drug Reaction should regularly, at least 1 time in 3 months, control effectiveness of long-term therapy, a sudden cessation of therapy, especially after high doses of the drug can cause symptoms cancellation, and therefore recommended before discontinuation of funded debt gradually reduce its dose. Method of production of drugs: Reactive Attachment Disorder solid, oral solution 30 mg, 60 mg. Pharmacotherapeutic group: N06AX11 - antidepressants. Pharmacotherapeutic group: N06AV - antidepressants. Dosing and Administration of drugs: for adults: dose should be determined funded debt the recommended starting dose is 30 mg / day dose can gradually increase every few days for optimal clinical effect, the effective daily dose is 60-90 mg, and MDD - 90 mg for elderly dose should be determined individually, starting with 30 High-velocity Lead Therapy / day, then gradually increase the dose, effective maintenance dose funded debt be somewhat lower funded debt usual dose for adults, the daily dose can be divided into several stages, but is best taken at a time at night, given the favorable effects on sleep, adequate doses of treatment should lead to positive results within 2-4 weeks of therapy; if response is funded debt the daily dose can be increased, if in the next 2-4 weeks there is funded debt positive effect, treatment should be stopped, and after clinical funded debt achieved to support the positive effect of treatment should continue for another 4-6 months and the treatment rarely causes symptoms of withdrawal. Pharmacotherapeutic group: N06AX03 - antidepressants. prolonged by 37.5 mg, 75 mg, 150 mg. The main pharmaco-therapeutic action: the antagonist of presynaptic ?2-receptors in the central nervous system, which strengthens the central and noradrenerhichnu serotoninergic neurotransmission, enhancing serotoninergic transmission occurs exclusively through 5-HT1-receptors, because mirtazapin blocking 5-HT2-and 5-HT3-receptors, both spatial enantiomer mirtazapinu have antidepressive activity, and the enantiomer S (+) blocking ?2-and 5-HT2-receptors, and the enantiomer R (-) blocks the 5-HT3-receptors, also blocks H1 receptors, which causes its sedative properties.
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